Gene and Disorder list

The GRID panel can screen in parallel 279 genes, including 2015 IUIS genes (IUIS publication), known to be causative of Primary Immune disorders.

The system is flexible and can rapidly incorporate new genes including the expected 2017 IUIS update.

 

Gene 2015 IUIS Classification
FAS Diseases of immune dysregulation and Phenocopies of PID
TBX1 Defects in intrinsic and innate immunity
STAT3 CID with associated or syndromic features
NLRP3 Auto-inflammatory disorders
IKBKG (NEMO) CID with associated or syndromic features
GATA2 Predominantly antibody deficiencies
DKC1 CID with associated or syndromic features
CYBB Congenital defects of phagocyte number, function, or both
CSF2RA Congenital defects of phagocyte number, function, or both and Phenocopies of PID
CARD11 Immunodeficiencies affecting cellular and humoral immunity
ZBTB24 CID with associated or syndromic features
XIAP Diseases of immune dysregulation
WIPF1 CID with associated or syndromic features
WAS Congenital defects of phagocyte number, function, or both
VPS45 Congenital defects of phagocyte number, function, or both
VPS13B Congenital defects of phagocyte number, function, or both
USB1 Congenital defects of phagocyte number, function, or both
ZAP70 Immunodeficiencies affecting cellular and humoral immunity
TNFRSF1A Auto-inflammatory disorders
TPP2 Diseases of immune dysregulation
TNFSF12 Predominantly antibody deficiencies
TNFRSF4 Immunodeficiencies affecting cellular and humoral immunity
TNFRSF13C Predominantly antibody deficiencies
TNFRSF13B (TACI) Predominantly antibody deficiencies
TMEM173 (STING) Diseases of immune dysregulation
TMC8 Defects in intrinsic and innate immunity
UNG Predominantly antibody deficiencies
TRAC Immunodeficiencies affecting cellular and humoral immunity
TRAF3 Defects in intrinsic and innate immunity
TRAF3IP2 Defects in intrinsic and innate immunity
UNC93B1 Defects in intrinsic and innate immunity
UNC13D Diseases of immune dysregulation
UNC119 Immunodeficiencies affecting cellular and humoral immunity
TYK2 Defects in intrinsic and innate immunity
TTC7A CID with associated or syndromic features
TTC37 Predominantly antibody deficiencies
TRNT1 Predominantly antibody deficiencies
TREX1 Diseases of immune dysregulation
STK4 Immunodeficiencies affecting cellular and humoral immunity
TAPBP Immunodeficiencies affecting cellular and humoral immunity
TAP2 Immunodeficiencies affecting cellular and humoral immunity
TAP1 Immunodeficiencies affecting cellular and humoral immunity
STXBP2 Diseases of immune dysregulation
STX11 Diseases of immune dysregulation
STIM1 CID with associated or syndromic features
STAT5B CID with associated or syndromic features
TMC6 Defects in intrinsic and innate immunity
TAZ Congenital defects of phagocyte number, function, or both
TBK1 Defects in intrinsic and innate immunity
TBX1 CID with associated or syndromic features
TLR3 Defects in intrinsic and innate immunity
TINF2 CID with associated or syndromic features
TICAM1 Defects in intrinsic and innate immunity
THBD Complement deficiencies
TERT CID with associated or syndromic features
TERC CID with associated or syndromic features
TCN2 CID with associated or syndromic features
TCF3 Predominantly antibody deficiencies
SEMA3E CID with associated or syndromic features
SH2D1A Diseases of immune dysregulation
SERPING1 Complement deficiencies
SBDS Congenital defects of phagocyte number, function, or both
SART3 Predominantly antibody deficiencies
SAMHD1 Diseases of immune dysregulation
RTEL1 CID with associated or syndromic features
RPSA Defects in intrinsic and innate immunity
STAT3 Diseases of immune dysregulation and Phenocopies of PID
SH3BP2 Auto-inflammatory disorders
SLC29A3 Auto-inflammatory disorders
STAT1 Defects in intrinsic and innate immunity
SPINK5 CID with associated or syndromic features
SP110 CID with associated or syndromic features
SMARCAL1 CID with associated or syndromic features
SLC46A1 CID with associated or syndromic features
STAT2 Defects in intrinsic and innate immunity
SLC37A4 Congenital defects of phagocyte number, function, or both
SLC35C1 Congenital defects of phagocyte number, function, or both
RAC2 Congenital defects of phagocyte number, function, or both
RAG2 Immunodeficiencies affecting cellular and humoral immunity
RAG1 Immunodeficiencies affecting cellular and humoral immunity
RORC Defects in intrinsic and innate immunity
RAB27A Diseases of immune dysregulation
PTPRC Immunodeficiencies affecting cellular and humoral immunity
PSTPIP1 Auto-inflammatory disorders
PSMB8 Auto-inflammatory disorders
PRKDC Immunodeficiencies affecting cellular and humoral immunity
RBCK1 CID with associated or syndromic features
RFX5 Immunodeficiencies affecting cellular and humoral immunity
RFXANK Immunodeficiencies affecting cellular and humoral immunity
RNF31 CID with associated or syndromic features
RNF168 CID with associated or syndromic features
RNASEH2C Diseases of immune dysregulation
RNASEH2B Diseases of immune dysregulation
RNASEH2A Diseases of immune dysregulation
RMRP CID with associated or syndromic features
RHOH Immunodeficiencies affecting cellular and humoral immunity
RFXAP Immunodeficiencies affecting cellular and humoral immunity
ORAI1 CID with associated or syndromic features
NRAS Phenocopies of PID
NOP10 CID with associated or syndromic features
NOD2 Auto-inflammatory disorders
NLRP3 Phenocopies of PID
NLRP12 Auto-inflammatory disorders
NLRC4 Auto-inflammatory disorders
NHP2 CID with associated or syndromic features
NHEJ1 Immunodeficiencies affecting cellular and humoral immunity
PRKCD Diseases of immune dysregulation
PARN CID with associated or syndromic features
PRF1 Diseases of immune dysregulation
POLE CID with associated or syndromic features
PNP CID with associated or syndromic features
PMS2 CID with associated or syndromic features
PLCG2 Auto-inflammatory disorders
PIK3R1 Predominantly antibody deficiencies
PIK3CD Predominantly antibody deficiencies
PGM3 CID with associated or syndromic features
MTHFD1 CID with associated or syndromic features
MS4A1 Predominantly antibody deficiencies
MRE11A Additional Tier 1 gene
MPO Additional Tier 1 gene
MOGS Predominantly antibody deficiencies
MEFV Auto-inflammatory disorders
MCM4 CID with associated or syndromic features
MBL2 Additional Tier 1 gene
MASP2 Complement deficiencies
NFKBIA CID with associated or syndromic features
MSH6 Predominantly antibody deficiencies
NFAT5 Diseases of immune dysregulation
MVK Auto-inflammatory disorders
MYD88 Defects in intrinsic and innate immunity
NBN CID with associated or syndromic features
NCF1 Congenital defects of phagocyte number, function, or both
NCF2 Congenital defects of phagocyte number, function, or both
NCF4 Congenital defects of phagocyte number, function, or both
NFKB2 Predominantly antibody deficiencies
NFKB1 CVID Additional Tier 1 gene
JAK3 Immunodeficiencies affecting cellular and humoral immunity
ITK Immunodeficiencies affecting cellular and humoral immunity
ITGB2 Congenital defects of phagocyte number, function, or both
ITGAM Complement deficiencies
ITCH Diseases of immune dysregulation
ISG15 Defects in intrinsic and innate immunity
IRF8 Defects in intrinsic and innate immunity
IRF7 Defects in intrinsic and innate immunity
MAP3K14 Immunodeficiencies affecting cellular and humoral immunity
JAGN1 Congenital defects of phagocyte number, function, or both
KRAS Phenocopies of PID
MALT1 Immunodeficiencies affecting cellular and humoral immunity
MAGT1 Immunodeficiencies affecting cellular and humoral immunity
LYST Diseases of immune dysregulation
LRBA Immunodeficiencies affecting cellular and humoral immunity
LPIN2 Auto-inflammatory disorders
LIG4 Immunodeficiencies affecting cellular and humoral immunity
LIG1 Additional Tier 1 gene
LCK Immunodeficiencies affecting cellular and humoral immunity
LAMTOR2 Congenital defects of phagocyte number, function, or both
IL12RB1 Defects in intrinsic and innate immunity
IL17F Defects in intrinsic and innate immunity
IL17A Phenocopies of PID
IL12B Defects in intrinsic and innate immunity
IL10RB Diseases of immune dysregulation
IL10RA Diseases of immune dysregulation
IL10 Diseases of immune dysregulation
IKZF1 (IKAROS) Additional Tier 1 gene
IRAK4 Defects in intrinsic and innate immunity
IL17RA Defects in intrinsic and innate immunity
IL17RC Defects in intrinsic and innate immunity
IL1RN Auto-inflammatory disorders
IL7R Immunodeficiencies affecting cellular and humoral immunity
IL36RN Auto-inflammatory disorders
IL2RG Immunodeficiencies affecting cellular and humoral immunity
IL2RA Diseases of immune dysregulation
IL22 Phenocopies of PID
INO80 Predominantly antibody deficiencies
IL21R Immunodeficiencies affecting cellular and humoral immunity
IL21 Immunodeficiencies affecting cellular and humoral immunity
FOXP3 Diseases of immune dysregulation
IKBKG (NEMO) Defects in intrinsic and innate immunity
FCN3 Complement deficiencies
FERMT3 Congenital defects of phagocyte number, function, or both
FOXN1 CID with associated or syndromic features
FPR1 Congenital defects of phagocyte number, function, or both
G6PC3 Congenital defects of phagocyte number, function, or both
GATA2 Congenital defects of phagocyte number, function, or both
GFI1 Congenital defects of phagocyte number, function, or both
HAX1 Congenital defects of phagocyte number, function, or both
ICOS Immunodeficiencies affecting cellular and humoral immunity
IKBKB Immunodeficiencies affecting cellular and humoral immunity
IGLL1 Predominantly antibody deficiencies
IGKC Predominantly antibody deficiencies
IGHM Predominantly antibody deficiencies
IFNGR2 Defects in intrinsic and innate immunity
IFNGR1 Defects in intrinsic and innate immunity
IFIH1 Diseases of immune dysregulation
DNMT3B CID with associated or syndromic features
FCGR3B Defects in intrinsic and innate immunity
CXCR4 Defects in intrinsic and innate immunity
CYBA Congenital defects of phagocyte number, function, or both
CYBB Defects in intrinsic and innate immunity
DCLRE1B CID with associated or syndromic features
DCLRE1C Immunodeficiencies affecting cellular and humoral immunity
DKC1 Predominantly antibody deficiencies
DOCK2 Immunodeficiencies affecting cellular and humoral immunity
DOCK8 Immunodeficiencies affecting cellular and humoral immunity
FASLG Diseases of immune dysregulation
FAS Phenocopies of PID
FADD Diseases of immune dysregulation
F12 Additional Tier 1 gene
EPG5 CID with associated or syndromic features
ELANE Congenital defects of phagocyte number, function, or both
FCGR3A Defects in intrinsic and innate immunity
CTSC Congenital defects of phagocyte number, function, or both
CFHR1 Complement deficiencies
CFHR2 Complement deficiencies
CFHR3 Complement deficiencies
CFHR4 Complement deficiencies
CFHR5 Complement deficiencies
CFI Complement deficiencies
CFP Complement deficiencies
CHD7 CID with associated or syndromic features
CIITA Immunodeficiencies affecting cellular and humoral immunity
CLPB Congenital defects of phagocyte number, function, or both
COPA Auto-inflammatory disorders
CORO1A Immunodeficiencies affecting cellular and humoral immunity
CR2 Predominantly antibody deficiencies
CSF2RA Phenocopies of PID
CSF3R Congenital defects of phagocyte number, function, or both
CTLA4 Diseases of immune dysregulation
CTPS1 Immunodeficiencies affecting cellular and humoral immunity
CFH Complement deficiencies
CFD Complement deficiencies
CD3G Immunodeficiencies affecting cellular and humoral immunity
CD3E Immunodeficiencies affecting cellular and humoral immunity
CD3D Immunodeficiencies affecting cellular and humoral immunity
CD27 Immunodeficiencies affecting cellular and humoral immunity
CD247 Immunodeficiencies affecting cellular and humoral immunity
CD19 Predominantly antibody deficiencies
CCBE1 CID with associated or syndromic features
CASP8 Diseases of immune dysregulation
CD40 Immunodeficiencies affecting cellular and humoral immunity
CD40LG Immunodeficiencies affecting cellular and humoral immunity
CD46 Complement deficiencies
CD59 Complement deficiencies
CD79A Predominantly antibody deficiencies
CD79B Predominantly antibody deficiencies
CD81 Predominantly antibody deficiencies
CD8A Immunodeficiencies affecting cellular and humoral immunity
CEBPE Congenital defects of phagocyte number, function, or both
ADA2 Diseases of immune dysregulation
CFB Complement deficiencies
CASP10 Diseases of immune dysregulation
C4B Complement deficiencies
C4A Complement deficiencies
C3 Complement deficiencies
C2 Complement deficiencies
C1S Complement deficiencies
C1R Complement deficiencies
C1QC Complement deficiencies
C1QB Complement deficiencies
C5 Complement deficiencies
C6 Complement deficiencies
CARD9 Defects in intrinsic and innate immunity
CARD14 Auto-inflammatory disorders
CARD11 Predominantly antibody deficiencies
C9 Complement deficiencies
C8G Complement deficiencies
C8B Complement deficiencies
C8A Complement deficiencies
C7 Complement deficiencies
C1QA Complement deficiencies
ARPC1B Additional Tier 1 gene
ATM CID with associated or syndromic features
B2M Immunodeficiencies affecting cellular and humoral immunity
BCL10 Immunodeficiencies affecting cellular and humoral immunity
BLM CID with associated or syndromic features
BLNK Predominantly antibody deficiencies
BLOC1S6 Diseases of immune dysregulation
BTK Predominantly antibody deficiencies
APOL1 Defects in intrinsic and innate immunity
AP3B1 Diseases of immune dysregulation
AK2 Immunodeficiencies affecting cellular and humoral immunity
ACD CID with associated or syndromic features
ACP5 Diseases of immune dysregulation
ACTB Congenital defects of phagocyte number, function, or both
ADA Immunodeficiencies affecting cellular and humoral immunity
ADAM17 Auto-inflammatory disorders
ADAR Diseases of immune dysregulation
AICDA Predominantly antibody deficiencies
AIRE Diseases of immune dysregulation